Dutch CF Registry 2017 - Symptoms and consequences

Complications

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Patients with CF can also develop other disorders, a phenomenon we call comorbidity. One of these is CF-related diabetes (CFRD). In principle, patients with CF who use pancreatic enzymes and who are older than 10, are tested for glucose tolerance every year. This test can show whether someone has CFRD and needs insulin. In 2017, 14% of children and 33% of adults had CFRD. 

Figure 1 below shows the percentage of (eligible) patients who underwent a glucose tolerance test in 2017.

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Figure 2 below shows the percentage of children and adults that have an additional disorder/illness.

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  • Allergic bronchopulmonary aspergillosis (ABPA) is a temporary allergic, severe reaction of the lungs to the fungus Aspergillus fumigatus.
  • Distal intestinal obstruction syndrome (DIOS) is the obstruction of the small intestine.
  • Liver disease due to an obstruction of the bile flow, possibly resulting in scarring. Occasionally, a liver transplant is ultimately necessary.
  • Gastro-esophageal reflux disease (GERD) means that gastric acid flows back into the esophagus and causes damage there.
  • Sinusitis is inflammation of the sinuses.
  • In osteopenia and osteoporosis, the bone is weakened due to a shortage of minerals such as calcium, with osteopenia being the precursor of osteoporosis.